Abdoulaye Doucoure has dealt Rafa Benitez and Everton a sizeable blow with the news that he will be sidelined for an extended period.
The midfielder, who has been ruled out with a foot injury, is an integral part of the Toffees side and his numbers show just how much of an influence he holds when on the pitch – Everton have won just 22.2 per cent of matches without him, compared to 51.1 per cent when he’s in the starting XI.
Here, Sportsmail takes a look at the most influential stars from your Premier League club.
Everton have been rocked by the news that Abdoulaye Doucoure has suffered another injury
Not the name Arsenal fans would have thought they couldn’t be doing without at the beginning of the season.
Yet Ramsdale’s form since stepping up to replace Bernd Leno in goal has been key to providing some much-needed resilience at the back.
The 23-year-old has kept three clean sheets in five league appearances since taking the No 1 mantle, and the Gunners remain unbeaten with him between the sticks.
Aaron Ramsdale has been key to a more solid Arsenal defence since coming into the line-up
The Scot is a key figure for both club and country at the minute in the middle of the park.
His three goal involvements from midfield for VIlla only tell a part of the story of the job he does for Dean Smith’s side.
A revelation in the Championship, Ivan Toney has continued his eye-catching form in the top flight.
His physical nature has seen some of the best defences in the league struggle to cope with his presence, as he played key roles in the matches against Liverpool and Arsenal – despite not actually finding the net.
Goals are beginning to come now, too, and he is certain to add to his two strikes – and two assists – as the campaign continues.
Ivan Toney continues to be the threat that he was in the Championship despite the step up
Not a name anyone affiliated with Brighton would have thought would appear on this list six months ago.
However, the Republic of Ireland international has returned a new man after a difficult loan spell at Celtic last season.
He has been a rock in the middle of defence, filling the void left by Ben White following his £50m move to Arsenal.
Still only 21, Dwight McNeil has started every match of the campaign for Burnley this season.
His direct style has endeared him to the Turf Moor faithful over recent seasons and the England Under-21 international will be key if Sean Dyche’s men are to start climbing the table and avoid a relegation dog-fight.
Another club where the importance of a solid goalkeeper has proved integral to success.
Already this season, the Senegal international has provided displays that have single-handedly secured three points for the Blues – his performance against Brentford just the latest example.
For talk of his Ballon d’Or shortlist snub to be so vocal, especially from his own team-mates, it gives you an indication of his standing within Thomas Tuchel’s side.
Edouard Mendy is fast cementing himself as the best goalkeeper in European football
It seems forever and a day now that Wilfried Zaha has been the go-to man at Selhurst Park.
It has been nearly seven years since he made his move back to south London from Manchester United, and he continues to be the man pulling the strings.
It has been no different under the guidance of new boss Patrick Vieira, as Zaha continues to impose himself on defences from the left wing.
While Rafa Benitez has had his fair share of injury woes already at Everton, this latest setback is certainly the most significant.
With Abdoulaye Doucoure on the pitch, Everton’s win record is 51 per cent. Without him, it’s just 22 per cent.
His importance in the side is clear, and his lengthy spell on the sidelines poses a major issue for the Spaniard.
While Marcelo Bielsa’s men have struggled to hit the heights of last season, their Brazilian is still dragging them in the right direction.
His three goals are helping fill the void left by a misfiring Patrick Bamford, and have been key to keeping Leeds’ heads above water.
Despite his advancing years, Jamie Vardy continues to be the man Leicester cannot do without.
At 34, his tireless run rate continues to terrify defences, and his seven goals in eight Premier League appearances this season shows there is no sign of his powers waning just yet.
Despite his age of 34, Jamie Vardy continues to be a thorn in the side of Premier League clubs
There isn’t a club in the world that would not feel the absence of Mohamed Salah.
Quickly being talked about in terms of the best striker in the world at this moment in time, the Egyptian continues to age like a fine wine.
He has scored in all but one of the Reds’ eight league matches this season, a patch of form that shows no sign of abating.
Yes, Kevin De Bruyne has a wand of a right foot… and his left foot’s not bad either. And yes, Phil Foden is coming on leaps and bounds under Pep Guardiola, too.
But if you want to see what makes Manchester City tick, then you should look no further than the German midfielder.
His presence has coincided with the side’s most dominant displays of the season – he was on target in the 5-0 drubbing of Arsenal, and put in a match-winning display against Leicester City.
While all the excitement at Old Trafford this campaign tends to revolve around another Portuguese star, Bruno Fernandes still holds the most influence.
Cristiano Ronaldo has popped up at the right time on several occasions already for Ole Gunnar Solskjaer’s men, but Fernandes’ consistency in the middle of the park is still what United need.
He has four goals – a total that would have been higher but for his disastrous penalty miss against Aston Villa – and two assists already this campaign, a tally that is certain to rise.
Bruno Fernandes might not be the big name on everyone’s lips at United, but he is pivotal
There is no denying it: when Callum Wilson is not on the pitch, Newcastle struggle to find goals.
His injury issues have held back the Magpies going forward this season, and his three goals in three appearances at St James’ Park this season tell you all you need to know about his importance.
The 31-year-old was pivotal two seasons ago in getting the Canaries firing in front of goal, and is proving the same this season.
Daniel Farke’s side are finding goals hard to come by and are already rooted to the bottom of the table.
If that is to change, then keeping Pukki as an everpresent up top in a bid to add to his two goals already this season will be key to their fortunes.
Teemu Pukki is as important to Norwich now as he was in the top flight two seasons ago
It is not just his set piece ability that makes James Ward-Prowse the first name on the team-sheet at St Mary’s.
The England international has grown into an integral part of Ralph Hasenhuttl’s side, and has taken the captain’s armband, too.
He is still adding the odd goal from the spot, but what he adds to Saints’ side goes far beyond.
A place usually reserved for Harry Kane, the role of Spurs talisman has fallen on the shoulders of Son this season.
Following the summer of speculation, the England international has not returned the same man, and his South Korean team-mate has picked up the mantle of Mr. Reliable.
The 29-year-old has grabbed four goals this season and continues to shine in front of goal. His influence will only heighten too as his partner in crime returns to form.
Son Heung-min has stepped up in the absence of an all-singing, all-dancing Harry Kane
There was some surprise that Watford were able to keep hold of Sarr in the Championship last season. His form since returning to the top flight has only cemented that sentiment.
Scoring four times in his first eight appearances in the league this season, his goals have helped deliver all seven of the club’s points this season.
Antonio’s influence on the pitch for West Ham knows no bounds.
Whether it’s scoring himself, or setting up team-mates, his attacking attributes have helped David Moyes’ men soar up the table this season, and have laid the foundations for another tilt at the European places.
With five goals and three assists already to his name, the 31-year-old is the one player the Hammers just cannot do without at the minute.
Michail Antonio appears to be leading yet another European charge for West Ham this season
An inspirational captain, Conor Coady is the kind of centre back every manager dreams of.
Solid in his own performances at the back, the talismanic skipper can also produce telling moments at the other end of the field.
That was the case on Saturday when he scored in Wolves’ stirring comeback against Aston Villa. There will be more moments to come from the England international this season, too.